Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Identifieur interne : 000538 ( Main/Exploration ); précédent : 000537; suivant : 000539Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Auteurs : Katharina Wulff [Royaume-Uni] ; Silvia Gatti [Suisse] ; Joseph G. Wettstein [Suisse] ; Russell G. Foster [Royaume-Uni]Source :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2010-08.
Abstract
Sleep and circadian rhythm disruption are frequently observed in patients with psychiatric disorders and neurodegenerative disease. The abnormal sleep that is experienced by these patients is largely assumed to be the product of medication or some other influence that is not well defined. However, normal brain function and the generation of sleep are linked by common neurotransmitter systems and regulatory pathways. Disruption of sleep alters sleep–wake timing, destabilizes physiology and promotes a range of pathologies (from cognitive to metabolic defects) that are rarely considered to be associated with abnormal sleep. We propose that brain disorders and abnormal sleep have a common mechanistic origin and that many co-morbid pathologies that are found in brain disease arise from a destabilization of sleep mechanisms. The stabilization of sleep may be a means by which to reduce the symptoms of — and permit early intervention of — psychiatric and neurodegenerative disease.
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DOI: 10.1038/nrn2868
Affiliations:
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Foster</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6726D4ED68B9F6D0C047F72D040D4AFB71416797</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1038/nrn2868</idno><idno type="url">https://api.istex.fr/document/6726D4ED68B9F6D0C047F72D040D4AFB71416797/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000F73</idno><idno type="wicri:Area/Main/Curation">000D90</idno><idno type="wicri:Area/Main/Exploration">000538</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease</title><author><name sortKey="Wulff, Katharina" sort="Wulff, Katharina" uniqKey="Wulff K" first="Katharina" last="Wulff">Katharina Wulff</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Katharina Wulff and Russell G. Foster are members of the Circadian and Visual Neuroscience group, Nuffield Laboratory of Ophthalmology, University of Oxford, Headley Way, Oxford, OX3 9DU</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Gatti, Silvia" sort="Gatti, Silvia" uniqKey="Gatti S" first="Silvia" last="Gatti">Silvia Gatti</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Silvia Gatti and Joseph G. Wettstein are at the Neuroscience Research, F. Hoffmann-La Roche Ltd., 4070 Basel</wicri:regionArea><wicri:noRegion>4070 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Wettstein, Joseph G" sort="Wettstein, Joseph G" uniqKey="Wettstein J" first="Joseph G." last="Wettstein">Joseph G. 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However, normal brain function and the generation of sleep are linked by common neurotransmitter systems and regulatory pathways. Disruption of sleep alters sleep–wake timing, destabilizes physiology and promotes a range of pathologies (from cognitive to metabolic defects) that are rarely considered to be associated with abnormal sleep. We propose that brain disorders and abnormal sleep have a common mechanistic origin and that many co-morbid pathologies that are found in brain disease arise from a destabilization of sleep mechanisms. 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